Logo der Universität Wien

Total synthesis of efomycine M

 

Barth, Roland; Mulzer, Johann.   

Angewandte Chemie, International Edition  (2007),  46(30),  5791-5794.

Two-directional synthesis: Key steps in the first total synthesis of the anti-inflammatory agent efomycine M (1) are a two-directional C11-C12 chain elongation and an early-stage dimerization reaction. The central stereopentad is synthesized by a highly stereoselective sequence consisting of an anti-aldol reaction and a diastereoselective reduction.

 

 

 

Johann Mulzer
Institute for Organic Chemistry
University of Vienna

Währingerstraße 38
A-1090 Vienna

University of Vienna | Universitätsring 1 | 1010 Vienna | T +43-1-4277-0