Logo der Universität Wien

Chiral Pool Synthesis: from α-Amino Acids and Derivatives

Mulzer, Johann

Comprehensive Chirality 2012, 2, 122-162.

Proteinogenic α-amino acids are readily available from Nature with enantiomeric purity. Both the amino and the carboxylic acid function are orthogonal and can be used for appropriate modification. The CN bond is generally maintained throughout the sequence, whereas the carboxylic acid is converted into a variety of derivatives, for instance alcohols, olefins, aldehydes, and so on. In this way chain elongation or formation of carbo- and heterocyclic rings is possible. This chapter covers the literature from 2000 onward and tries to give a representative though not comprehensive review of the synthesis of a wide variety of nitrogen containing natural products.

Johann Mulzer
Institute for Organic Chemistry
University of Vienna

Währingerstraße 38
A-1090 Vienna

University of Vienna | Universitätsring 1 | 1010 Vienna | T +43-1-4277-0