Synthesis of the cyclobutane moiety of providencin

Gaich, Tanja; Arion, Vladimir; Mulzer, Johann.

Heterocycles  (2007),  74  855-862.

A short and stereoselective synthesis of the protected cyclobutane diol moiety of the natural compound providencin is reported. Key step is the chemo- and stereoselective hydroboration of the silyl-enol ether obtained from commercially available bicyclo[3.2.0]hept-6-en-2-one.