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Synthesis of the cyclobutane moiety of providencin


Gaich, Tanja; Arion, Vladimir; Mulzer, Johann.

Heterocycles  (2007),  74  855-862.

A short and stereoselective synthesis of the protected cyclobutane diol moiety of the natural compound providencin is reported. Key step is the chemo- and stereoselective hydroboration of the silyl-enol ether obtained from commercially available bicyclo[3.2.0]hept-6-en-2-one.



Johann Mulzer
Institute for Organic Chemistry
University of Vienna

Währingerstraße 38
A-1090 Vienna

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