Total synthesis of efomycine M

Barth, Roland; Mulzer, Johann.   

Angewandte Chemie, International Edition  (2007),  46(30),  5791-5794.

Two-directional synthesis: Key steps in the first total synthesis of the anti-inflammatory agent efomycine M (1) are a two-directional C11-C12 chain elongation and an early-stage dimerization reaction. The central stereopentad is synthesized by a highly stereoselective sequence consisting of an anti-aldol reaction and a diastereoselective reduction.