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Total synthesis of efomycine M


Barth, Roland; Mulzer, Johann.   

Angewandte Chemie, International Edition  (2007),  46(30),  5791-5794.

Two-directional synthesis: Key steps in the first total synthesis of the anti-inflammatory agent efomycine M (1) are a two-directional C11-C12 chain elongation and an early-stage dimerization reaction. The central stereopentad is synthesized by a highly stereoselective sequence consisting of an anti-aldol reaction and a diastereoselective reduction.




Johann Mulzer
Institute for Organic Chemistry
University of Vienna

Währingerstraße 38
A-1090 Vienna

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