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A Diels-Alder approach to (-)-ovalicin


Tiefenbacher, Konrad; Arion, Vladimir B.; Mulzer, Johann.   

Angewandte Chemie, International Edition  (2007),  46(15),  2690-2693.

A round at the Oval: The antiangiogenic activity of the natural product ovalicin has sparked significant interest. A highly efficient enantio- and diastereoselective total synthesis of ovalicin proved successful in which the key step involved an endo selective Diels-Alder reaction (see scheme, PG=protecting group).



Johann Mulzer
Institute for Organic Chemistry
University of Vienna

Währingerstraße 38
A-1090 Vienna

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