A Non-Diels−Alder Approach to the cis-Decalin Core of Branimycin

Valentin S. Enev*, Martina Drescher, and Johann Mulzer*

Org. Lett., 2008, 10 (3), pp 413–416

The synthesis of the highly substituted cis-decalin core of branimycin has been accomplished. A catalytic copper mediated SN2‘ opening of oxabicycle 7 with Grignard reagent and ring-closing metathesis served as key transformations.