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Short Formal Synthesis of (-)-Platencin

Konrad Tiefenbacher*, Johann Mulzer, Prof.*

Angewandte Chemie, International Edition (2008), 47(33), 6199-6200.

Short and sweet: A five-step, protecting-group-free formal synthesis of (-)-platencin from commercially available (-)-perillaldehyde (see retrosynthetic scheme) features a highly diastereoselective Diels-Alder reaction and a ring-closing metathesis as key steps.

 

 

Johann Mulzer
Institute for Organic Chemistry
University of Vienna

Währingerstraße 38
A-1090 Vienna

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