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Total Synthesis of the Antibiotic Kendomycin by Macrocyclization using Photo-Fries Rearrangement and Ring-Closing Metathesis

Magauer, Thomas; Martin, Harry J.; Mulzer, Johann.   

Angewandte Chemie, International Edition  (2009),  48(33),  6032-6036, S6032/1-S6032/132. 

Crossing swords: Two novel approaches to the antibiotic kendomycin are described. Salient features are complex Claisen-Ireland rearrangements and macrocyclizations by ring-closing metathesis (RCM) and a photo-Fries rearrangement (see retrosynthesis scheme).

 

Johann Mulzer
Institute for Organic Chemistry
University of Vienna

Währingerstraße 38
A-1090 Vienna

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