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From Silphinenes to Penifulvins: A Biomimetic Approach to Penifulvins B and C

Tanja Gaich and Johann Mulzer

Org. Lett., 2010, 12 (2), pp 272–275

 

The biomimetic total synthesis of penifulvins B and C uses a meta-photocycloaddition as a key step which gives rapid access to the fenestrane-type carboskeleton with control of an onring quaternary stereocenter. The route is concise, stereocontrolled, scaleable, and flexibile and requires only one protecting group.

 

 

Johann Mulzer
Institute for Organic Chemistry
University of Vienna

Währingerstraße 38
A-1090 Vienna

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