A Non-Photochemical Approach to the Bicyclo[3.2.0]heptane Core of Bielschowskysin

Fracet, Jean-Baptiste; Himmelbauer, Martin; Mulzer, Johann

Org. Lett. 2012, 14(9), 2195-2197.

An asymmetric synthesis of the tricyclic core (−)-1 of the marine diterpene bielschowskysin is described. In particular, a methodology was developed to introduce the crucial quaternary center at C-12.